Septin 12 (SEPT12)

Septins are a group of highly conserved GTP binding proteins found in eukaryotes. In yeast cells, they build scaffolding to provide structural support during cell division and compartmentalize parts of the cell. Septins, such as SEPT12, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia. By searching databases for members of the septin family, Hall et al. (2005) identified SEPT12. DNA microarray analysis showed low expression of SEPT12 in all normal, diseased, and cancer tissues examined.By genomic sequence analysis, Hall et al. (2005) mapped the SEPT12 gene to chromosome 16p13.3.