Matrix Remodelling Associated Protein 7 (MXRA7)

MXRA7 is a matrix remodelling associated gene and thus may be implicated in the development of cancer. UBE2-230k is a ubiquitin-conjugating enzyme and CG5013-like is homologous to a Drosophila gene showing similarity to zinc metalloproteases. Little is known about the function of the KIAA0585 gene except that it shows similarity to a phosphatidylserine receptor, whilst AANAT is an arylalkylamine N-acetyltransferase involved in melatonin formation and may not be a strong candidate. However, since polymorphisms in the arylamine N-acetyltransferases 1 and 2 (NAT1, NAT2) have been implicated in oesophageal and breast cancer, and RT-PCR data has indicated that AANAT is ubiquitously expressed in a variety of tissues including oesophagus and skin, analysis of this gene was undertaken.