G Protein Gamma 12 (GNg12)

Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins.  Currently, 16 different members of the alpha subunit family, 5 different members of the beta subunit family, and 11 different members of the gamma subunit family have been described in mammals.Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene. Gng12 is a negative regulator of the LPS response and may be an important factor in the overall inflammatory signaling cascade.