Natural Killer Cell Group 7 Sequence (NKG7)

Activated natural killer (NK) cells and T cells share many cytolytic components and surface antigens. The deduced 148-amino acid type I integral transmembrane protein has a signal sequence, a 38-residue external domain with multiple T-cell epitopes but no N-glycosylation sites or cysteine residues, and a 64-amino acid cytoplasmic domain with several phosphorylation sites. Northern blot analysis detected expression of a 0.9-kb transcript in activated NK and T cells, as well as in kidney, liver, lung, and pancreas. Shimane et al. (1994) obtained a cDNA encoding granulocyte colony-stimulating factor (GCSF, or CSF3)-induced gene-1, or GIG1.Sequence analysis predicted that the 165-amino acid protein contains 4 repetitive hydrophobic regions. Northern blot analysis revealed a 0.9-kb transcript primarily in myeloid cell lines.