RNA Exonuclease 4 Homolog (REXO4)

XPMC2 is a Xenopus gene identified on the basis of its ability to correct a mitotic defect in S. pombe. Using an exon trapping strategy, Kwiatkowska et al. (1997) identified a human homolog of XPMC2 within a BAC from chromosomal region 9q34. The gene, which they designated XPMC2H, encodes a predicted 422-amino acid protein. Like the Xenopus protein, XPMC2H is a basic protein, with a pI of 10.6, and contains a nuclear localization signal and potential CDC2 kinase sites. The 2 protein sequences are 52% identical.The XPMC2H gene contains 8 exons.Kwiatkowska et al. (1997) mapped the XPMC2H gene to chromosome 9q34.