Phosphoglucomutase 2 Like Protein 1 (PGM2L1)

The deduced 622-amino acid PGM2L1 protein has a molecular mass of 72 kD and shares 60% sequence identity with the PGM2 protein. Sequence analysis suggested that PGM2L1 is a cytosolic protein. Quantitative RT-PCR of mouse tissues showed that PGM2L1 was mainly expressed in brain where glucose-1,6-bisphosphate synthase activity was previously shown to be particularly high. High expression was also detected in testis, and intermediate expression was found in thymus, spleen, lung, and skeletal muscle.PGM2 acted more than 10-fold better as a phosphopentomutase than as a phosphoglucomutase, while PGM2L1 was about 5- to 20-fold better in catalyzing the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates.