N-Acetylated Alpha Linked Acidic Dipeptidase Like Protein 2 (NAaLADL2)

Northern blot analysis identified up to 6 different transcripts in the 1- to 10-kb range with strongest expression in kidney and placenta; embryonic expression was largely confined to duodenal and stomach endoderm, mesonephros, metanephros, and pancreas. Multiple protein isoforms were defined by different N-terminal regions, and by differential protein truncation/use of alternative C-terminal sequences attributable to alternative splicing/polyadenylation. Outside the N-terminal regions, the predicted proteins showed significant homology to N-acetylated alpha-linked acidic dipeptidase and transferrin receptors. Full-length NAALADL2 encodes a deduced 795-amino acid protein which shares 74% sequence identity with the mouse ortholog.